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Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents

Chih-Hua Tseng, You-Ren Chen, Cherng-Chyi Tzeng, Wangta Liu, Chon-Kit Chou, Chien-Chih Chiu* and Yeh-Long Chen*

2016

108:258-73

European Journal of Medicinal Chemistry

Prospective analysis of UGT1A1 promoter polymorphism for irinotecan dose escalation in metastatic colorectal cancer patients treated with bevacizumab plus FOLFIRI as the first-line setting: study protocol for a randomized controlled trial.

Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Jui-Ho Wang, Yi-Wen Lin, Hsiu-Chih Tang, Yung-Chuan Sung, Chang-Chieh Wu, Chien-Yu Lu* and Jaw-Yuan Wang*

2016

17:46

Trials

A New Anthraquinone Glycoside from Rhamnus nakaharai and Anti-tyrosinase Effect of 6-Methoxysorigenin

Tzy-Ming Lu* and Horng-Huey Ko

2016

1:1-7

Natural Product Research

Six new metabolites produced by Colletotrichum aotearoa 09F0161, an endophytic fungus isolated from Bredia oldhamii

Yi Hsiao, Ming-Jen Cheng*, Hsun-Shuo Chang*, Ming-Der Wu, Sung-Yuan Hsieh, Ta-Wei Liu, Chu-Hung Lin, Gwo-Fang Yuan and Ih-Sheng Chen*

2016

30: 251-258

Natural Product Research

Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Yi-Ping Fang, Chih-Hung Chuang, Pao-Chu Wu, Yaw-Bin Huang, Cherng-Chyi Tzeng, Yeh-Long Chen, Ya-Ting Liu, Yi-Hung Tsai and Ming-Jun Tsai*

2016

10:1019-1028

Drug Design, Development and Therapy

Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage

Hsun-Shuo Chang, Jen-Yang Tang, Ching-Yu Yen, Hurng-Wern Huang, Chang-Yi, Wu, Yi-An Chung, Ih-Sheng Chen, Ming-Yii Huang* and Hsueh-Wei Chang*

2016

16:94

BMC Complementary and Alternative Medicine

Nonapnea Sleep Disorders and the Risk of Acute Kidney Injury: A Nationwide Population-Based Study

Hugo You-Hsien Lin, Kai-Ting Chang, Yu-Han Chang, Tzongshi Lu, Chan-Jung Liang, Dean-Chuan Wang, Jui-Hsiu Tsai, Chung-Yao Hsu, Chi-Chih Hung, Mei-Chuan Kuo, Chang-Shen Lin and Shang-Jyh Hwang*

2016

95:e3067

Medicine

Secondary metabolites and bioactivity of the endophytic fungus Phomopsis theicola from Taiwanese endemic plant

Yi Hsiao, Hsun-Shuo Chang, Ta-Wei Liu, Sung-Yuan Hsieh, Gwo-Fang Yuan, Ming-Jen Cheng* and Ih-Sheng Chen*

2016

10:189-194

Records of Natural Products

Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway

Jung-Sheng Yu, Wei-Chun Chen, Chin-Kai Tseng, Chun-Kuang Lin, Yao-Chin Hsu, Yen-Hsu Chen* and Jin-Ching Lee*

2016

11:e0152236

PLOS ONE

Chemical constituents and bioactivities of Formosan Lauraceous plants

Hsun-Shuo Chang and Ih-Sheng Chen*

2016

24: 247-263

Journal of Food and Drug Analysis

Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxy isoflavone topical administration

Pao-Hsien Huang, Stephen Chu-Sung Hu, Chiang-Wen Lee, Chih-Hua Tseng* and Feng-Lin Yen*

2016

11:1615-1627

International Journal of Nanomedicine

Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients.

I‑Ping Yang, Hsiang‑Lin Tsai, Zhi‑Feng Miao, Ching‑Wen Huang, Chao‑Hung Kuo, Jeng‑Yih Wu, Wen‑Ming Wang, Suh‑Hang Hank Juo and Jaw‑Yuan Wang*

2016

14:108

Journal of Translational Medicine

Factors  affecting  number  of  lymph  nodes  harvested  and  the  impact  of  examining  a  minimum  of  12  lymph  nodes in  stage  I-III  colorectal  cancer  patients: a  retrospective  single  institution  cohort  study  of  1167 consecutive patients

Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Cheng-Jen Ma, Chao-Wen Chen, Chien-Yu Lu, Ming-Yii Huang, I-Ping Yang and Jaw-Yuan Wang*

2016

16: 17

BMC Surgery

High Blood Sugar Levels Significantly Impact the Prognosis of Colorectal Cancer Patients through Down-regulation of MicroRNA-16 by Targeting Myb and VEGFR2.

I-Ping Yang, Hsiang-Lin Tsai(共同第一), Ching-Wen Huang, Chien-Yu Lu, Zhi-Feng Miao, Se-Fen Chang, Suh-Hang Hank Juo and Jaw-Yuan Wang*

2016

7:18837-50

Oncotarget

Quinoline-Based Compound BPIQ Exerts Anti-Proliferative Effects on Human Retinoblastoma Cells via Modulating Intracellular Reactive Oxygen Species

Kai-Chun Cheng, Chun-Tzu Hung, Kuo-Jen Chen, Wen-Chuan Wu, Jau-Ling Suen, Cheng-Hsien Chang, Chi-Yu Lu, Chih-Hua Tseng , Yeh-Long Chen* and Chien-Chih Chiu*

2016

64:139-47

Archivum immunologiae et therapiae experimentalis

Serine protease inhibitor Kazal type 1 (SPINK1) as a prognostic marker in stage IV colon cancer patients receiving cetuximab based targeted therapy.

Yi-Ting Chen, Shu-Chuan Tsao, Hung-Pei Tsai, Jaw-Yuan Wang and Chee-Yin Chai*

2016

69:974-978

Journal of Clinical Pathology

Sesquiterpenoids and diterpenoids from the wood of Cunninghamia konishii and their inhibitory activities against NO production

Chi-I Chang, Chien-Chih Chen, Che-Yi Chao, Sheng-Yang Wang, Hsun-Shuo Chang, Ping-Jyun Sung, Guan-Jhong Huang, Yen-Cheng Li and Yueh-Hsiung Kuo*

2016

21: 490

Molecules

Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes

Hsiang-Lin Tsai, Ching-Wen Huang, Chao-Wen Chen, Yung-Sung Yeh, Cheng-Jen Ma and Jaw-Yuan Wang*

2016

40:1002-1009

World Journal of Surgery

Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2

Yuan-Bin Cheng,  Jin-Ching Lee, I-Wen Lo, Shu-Rong Chen, Hao-Chun Hu, Yu-Hsuan Wu,Yang-Chang Wu and Fang-Rong Chang*

2016

26:2344-2348

Bioorganic & Medicinal Chemistry Letters

Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2

Yuan-Bin Cheng, Jin-Ching Lee, I-Wen Lo, Shu-Rong Chen, Hao-Chun Hu, Yu-Hsuan Wu, Yang-Chang Wu*, Fang-Rong Chang*

2016

26:2344-2348

Bioorganic & Medicinal Chemistry Letters

Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-MethyltransferaseEnhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma

Rajni Kant, Chia-Hung Yen(共同第一), Chung-Kuang Lu, Ying-Chi Lin, Jih-Heng Li and Yi-Ming Arthur Chen

2016

17:669

International Journal of Molecular Sciences

Kinetics of Anatase Transition to Rutile TiO2 from Titanium Dioxide Precursor Powders Synthesized by a Sol-gel Process

Cheng-Li Wang, Weng-Sing Hwang, Hsueh-Liang Chu, Huey-Jiuan Lin, Horng-Huey Ko* and Moo-Chin Wang*

2016

42:13136-13143

Ceramics International

Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer

Jung-Yu Kan, Meng-Chi Yen, Jaw-Yuan Wang, Deng-Chyang Wu, Yen-Jung Chiu, Ya-Wen Ho and Po-Lin Kuo*

2016

7:31336-49

Oncotarget

Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage

Hsueh-Wei Chang, Jen-Yang Tang, Ching-Yu Yen, Hsun-Shuo Chang, Hurng-Wern Huang, Yi-An Chung, Ih-Sheng Chen and Ming-Yii Huang*

2016

92:263-272

International Journal of Radiation Biology

Terpene alkaloidal glucosides and apocarotenoids from Symplocos anomala

Cheng-I Huang, Hsun-Shuo Chang, Chu-Hung Lin and Ih-Sheng Chen*

2016

52:560-563

Chemistry of Natural Compounds

The X-linked inhibitor of apoptosis protein is an independent prognostic marker for rectal adenocarcinoma after preoperative chemoradiotherapy.

Yi-Ting Chen, Shu-Chuan Tsao, Hung-Pei Tsai, Jaw-Yuan Wang and Chee-Yin Chai*

2016

468:559-567

Virchows Archiv

Action-Monitoring Dysfunction in Obstructive Sleep Apnea - A Pilot Study

Ping-Song Chou, Chung-Yao Hsu, Meng-Ni Wu, Li-Min Liou, Shinag-Ru Lu, Ching-Kuan Liu and Chiou-Lian Lai*

2016

11:e0157575

PLOS ONE

Robotic surgery with high dissection and low ligation technique for consecutive patients with rectal cancer following preoperative concurrent chemoradiotherapy

Ching-Wen Huang, Yung-Sung Yeh, Wei-Chih Su, Hsiang-Lin Tsai, Tak-Kee Choy, Ming-Yii Huang, Chun-Ming Huang, I-Chen Wu, Huang-Ming Hu, Wen-Hung Hsu, Yu-Chung Su and Jaw-Yuan Wan*

2016

31:1169-1177

International Journal of Colorectal Disease

Self-Reported Napping Behavior Change After Continuous Positive Airway Pressure Treatment in Older Adults with Obstructive Sleep Apnea

Cheng-Fang Hsieh, Renata L. Riha, Ian Morrison and Chung-Yao Hsu*

2016

64:1634-9

Journal of the American Geriatrics Society

TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP

Hsien-Feng Liao, Chien-Chin Lee, Pei-Chi Hsiao, Yi-Fong Chen, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yeh-Long Chen, Jui-Chang Chen, Ya-Sian Chang* and Jan-Gowth Chang*

2016

82:649-659

Biomedicine & Pharmacotherapy

Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana

Pei-Yu Hsiao, Shiow-Ju Lee, Ih-Sheng Chen, Hsing-Yu Hsu and Hsun-Shuo Chang*

2016

130:282-290

Phytochemistry

Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.

Tzu-Po Chuang, Jaw-Yuan Wang, Shu-Wen Jao, Chang-Chieh Wu, Jiann- Hwa Chen, Koung-Hung Hsiao, Chung-Yen Lin, Shu-Hwa Chen, Sheng-Yao Su, Ying-Ju Chen, Yuan-Tsong Chen, Deng-Chyang Wu* and Ling-Hui Li*

2016

7:45803-45818

Oncotraget

Anti-Dengue Virus Constituents from Formosan
Zoanthid Palythoa mutuki

Jin-Ching Lee, Fang-Rong Chang, Shu-Rong Chen, Yu-Hsuan Wu, Hao-Chun Hu, Yang-Chang Wu, Anders Backlund and Yuan-Bin Cheng

2016

14:151

Marine drugs

Anti-Dengue Virus Constituents from Formosan
Zoanthid Palythoa mutuki

Jin-Ching Lee, Fang-Rong Chang, Shu-Rong Chen, Yu-Hsuan Wu,
Hao-Chun Hu, Yang-Chang Wu, Anders Backlund and Yuan-Bin Cheng*

2016

14:151

Marine Drugs

Clinical Implications and Future Perspectives of Circulating Tumor Cells and Biomarkers in Clinical Outcomes of Colorectal Cancer.

Ming-Yii Huang, Hsiang-Lin Tsai, Joh-Jong Huang*, Jaw-Yuan Wang*

2016

9:340-347

Translational 

Oncology

Eupafolin Nanoparticles Protect HaCaT Keratinocytes from Particulate Matter-induced Inflammation and Oxidative Stress

Zih-Chan Lin, Chiang-Wen Lee, Ming-Horng Tsai, Horng-Huey Ko, Jia-You Fang, Yao-Chang Chiang, Chan-Jung Liang, Lee-Fen Hsu, Stephen Chu-Sung Hu* and Feng-Lin Yen*

2016

11:3907-3926

International Journal of Nanomedicine

Human heme oxygenase 1 is a potential host cell factor against dengue virus replication

Chin-Kai Tseng, Chun-Kuang Lin, Yu-Hsuan Wu, Yen-Hsu Chen, Wei-Chun Chen, Kung-Chia Young* and Jin-Ching Lee*

2016

6:32176

Scientific Reports

An Observational Study of Extending FOLFOX Chemotherapy, Lengthening the Interval between Radiotherapy and Surgery, and Enhancing Pathological Complete Response Rates in Rectal Cancer Patients Following Preoperative Chemoradiotherapy.

Chun-Ming Huang, Ming-Yii Huang, Hsiang-Lin Tsai, Ching-Wen Huang, Cheng-Jen Ma, Yung-Sung Yeh, Suh-Hang Juo, Chih-Jen Huang and Jaw-Yuan Wang*

2016

9:702-712

Therapeutic Advances in Medical Oncology

Secondary metabolites of the endophytic fungus Lachnum abnorme from Ardisia cornudentata

Hsun-Shuo Chang, Chu-Hung Lin, Yi-Shuan Chen, Hui-Chun Wang, Hing-Yuen Chan, Sung-Yuan Hsieh, Ho-Cheng Wu, Ming-Jen Cheng*, Gwo-Fang Yuan, Shan-Yu Lin, Yue-Jin Lin and Ih-Sheng Chen*

2016

17:1512

International Journal of Molecular Sciences

Three New Abietane-type Diterpenes from the Bark of Cryptomeria japonica

Chi-I Chang, Chien-Chih Chen, Sheng-Yang Wang, Che-Yi Chao, Louis Kuoping Chao, Jih-Jung Chen, Horng-Huey Ko, Cheng-Chi Chen and Yueh-Hsiung Kuo*

2016

99:701-715

Helvetica Chimica Acta

A Prospective Study of Comparing Multi-Gene Biomarker Chip and Serum Carcinoembryonic Antigen in the Postoperative Surveillance for Patients with Stage I-III Colorectal Cancer

Yu-Tang Chang, Ming-Yii Huang, Yung-Sung Yeh, Ching-Wen Huang,Hsiang-Lin Tsai, Tian-Lu Cheng and Jaw-Yuan Wang*

2016

11:e0163264

PLOS ONE

Isolation of phorbol esters from Euphorbia grandicornis and evaluation of protein kinase C- and platelet-activating effects of Euphorbiaceae diterpenes in human platelets

Ju-Ying Tsai, Dóra Rédei, Peter Forgo, Yu Li, Andrea Vasas, Judit Hohmann* and Chin-Chung Wu*

2016

79:2658-2666

Journal of Natural Products

New species of the fern genus Lindsaea (Lindsaeaceae) from New Guinea with notes on the phylogeny of L. sect. Synaphlebium

Shi-Yong Dong*, Zheng-Yu Zuo, Yi-Shan Chao, Kipiro Damas and Bernard Sule

2016

11:e0163686

PLOS ONE

Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation

Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du, Anders Backlund, Tsong-Long Hwang, Chin-Chung Wu, Yuan-Bing Cheng*, Yang-Chang Wu*

2016

79:2674-2680

Journal of Natural Products

Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation

Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du, Tsong-Long Hwang, Yuan-Bin Cheng* and Yang-Chang Wu*

2016

79: 26742680

Journal of Natural Products

Attenuation of antigen-specific T helper 1 immunity by Neolitsea hiiranensis and its derived terpenoids

Yin-Hua Cheng, Ih-Sheng Chen, Ying-Chi Lin, Chun-Wei Tung, Hsun-Shuo Chang and Chia-Chi Wang*

2016

4: e2758

PeerJ

Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway

Ching-Ying Kuo, István Zupkó, Fang-Rong Chang, Attila Hunyadi, Chin-Chung Wu, Teng-Song Weng and Hui-Chun Wang*

2016

311:99-105

Toxicology and Applied Pharmacology

New chemical constituents from the endophytic fungus Xylaria papulis cultivated on Taiwanese Lepidagathis stenophylla

Yi-Shuan Chen, Hsun-Shuo Chang*, Hing-Yuen Chan, Ming-Der Wu, Ta-Wei Liu, Sung-Yuan Hsieh, Hui-Chun Wang, Chu-Hung Lin, Ming-Jen Cheng* and Ih-Sheng Chen*

2016

10:735-743

Records of Natural Products

New Diterpenes from Grangea maderaspatana

Fang-Rong Chang, Shih-Ting Huang, Ming-Hong Yen, Tsong-Long Hwang, Ching-Yeu Chen, Ming-Feng Hou, Shyng-Shiou Yuan, Yuan-Bin Cheng* and Yang-Chang Wu*

2016

131:124-129

Phytochemistry

Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules

Wen-Wei Lin, Yuan-Chin Hsieh, Yi-An Cheng, Kuo-Hsiang Chuang, Chien-Chiao Huang, Chih-Hung Chuang, I-Ju Chen, Kai-Wen Cheng, Yun-Chi Lu, Ta-Chun Cheng, Yeng-Tseng Wang, Steve R. Roffler and Tian-Lu Cheng

2016

88:12371-12379

Analytical Chemistry

Grape Seed Extract Attenuates Hepatitis C Virus Replication and Virus-Induced Inflammation.

Wei-Chun Chen, Chin-Kai Tseng, Bing-Hung Chen, Chun-Kuang Lin and Jin-Ching Lee*

2016

7:490

Frontiers in Pharmacology

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles.

Yuan-Chin Hsieh, Ta-Chun Cheng(共同第一), Hsin-Ell Wang, Jia-Je Li, Wen-Wei Lin,Chien-Chiao Huang, Chih-Hung Chuang, Yeng-Tseng Wang, Jaw-Yuan Wang, Steve R. Roffler, Kuo-Hsiang Chuang* and Tian-Lu Cheng*

2016

6:39119.

Scientific Reports

Development of pH-sensitive cationic PEGylated solid lipid nanoparticles for selective cancer-targeted therapy. Journal of Biomedical Nanotechnology.

Chih-Hung Chuang, Pao-Chu Wu, Teng-Huang Tsai, Yi-Ping Fang, Yi-Hung Tsai, Ta-Chun Cheng, Chien-Chaio, Huang, Ming-Yii Huang, Fang-Ming Chen, Yuan-Chin Hsieh, Wen-Wei Lin, Ming-Jun Tsai and Tian-Lu Cheng*

2016

13:192-203

Journal of Biomedical Nanotechnology

Risk of bipolar disorder in patients with COPD: a population-based cohort study

Pei-Jung Tsai, Yin-To Liao,Charles Tzu-Chi Lee, Chung-Yao Hsu, Ming-Hong Hsieh, Chia-Jui Tsai, Ming-Han Hsieh and Vincent Chin-Hung Chen*

2016

41:6-12

General Hospital Psychiatry

 

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